Investigating the Efficacy of Salmon DNA-Derived PDRN in Microbiome Preservation and pH Homeostasis During Dermal Cleansing

The Dermal Frontier: Preserving Microbiome and pH Homeostasis During Cleansing

The skin's surface is a dynamic ecosystem, serving as our primary defense against environmental aggressors. Central to this defense is the delicate balance of the dermal microbiome—a complex community of microorganisms—and the maintenance of an optimal acidic pH, typically ranging from 4.5 to 5.5. This acid mantle, coupled with a robust epidermal barrier, is crucial for preventing pathogen colonization, regulating hydration, and mitigating inflammatory responses. Daily dermal cleansing, while essential for removing impurities and pollutants, presents a significant challenge to this intricate homeostasis. Traditional cleansing agents can often disrupt the acid mantle, strip essential lipids, and dysregulate the microbiome, leading to compromised barrier function, increased transepidermal water loss (TEWL), and heightened susceptibility to irritation and sensitivity. Our research at CureNex explores advanced biomolecules capable of mitigating these detrimental effects, focusing on proactive preservation of dermal integrity even during routine cleansing.

The Salvage Pathway: PDRN's Role in Cellular Regeneration and Dermal Resilience

At the forefront of our investigation is Polydeoxyribonucleotide (PDRN), a highly purified deoxyribonucleic acid (DNA) fragment derived from salmon. Unlike larger DNA molecules, PDRN consists of low molecular weight polynucleotides that are readily bioavailable to dermal cells. Its primary mechanism of action hinges on the activation of the cellular "Salvage Pathway." Instead of requiring cells to expend significant energy on *de novo* synthesis of nucleosides and nucleotides—the fundamental building blocks of DNA and RNA—PDRN provides these precursors directly. By supplying exogenous purine and pyrimidine bases, PDRN allows cells to conserve ATP, redirecting metabolic energy towards essential processes such as fibroblast proliferation and extracellular matrix (ECM) component synthesis (e.g., collagen, elastin). This expedited cellular regeneration and repair capability directly enhances the skin's intrinsic capacity to restore its structural integrity post-cleansing. Clinical studies suggest this molecular facilitation fortifies the epidermal barrier, thereby supporting the natural environment required for microbiome stability and pH equilibrium.

Synergistic Action: PDRN and Hyaluronic Acid for Optimized Dermal Function

The efficacy of PDRN in maintaining dermal homeostasis is significantly amplified through synergistic formulations. The Curenex Hydrating Cleanser integrates PDRN with Sodium DNA, alongside Hyaluronic Acid (HA) and Glycerin. While PDRN drives intrinsic cellular repair and regeneration via the Salvage Pathway, Hyaluronic Acid, a prominent glycosaminoglycan, serves as a powerful humectant. Its remarkable capacity to bind and retain up to 1,000 times its weight in water creates an optimal hydrated microenvironment within the stratum corneum. This sustained hydration is paramount for several reasons: it ensures the proper functioning of enzymatic processes involved in desquamation and barrier repair, prevents excessive transepidermal water loss (TEWL) during and after cleansing, and physically plumps the skin, enhancing its resilience. The combined action of PDRN repairing and regenerating dermal structures, and HA providing crucial hydration, results in a more robust, supple, and biochemically stable epidermal barrier, effectively mitigating the disruptive potential of daily cleansing and promoting long-term dermal vitality.

Clinical Expectations: Fostering Post-Cleansing Dermal Harmony

Integrating a PDRN-infused cleanser into a daily skincare regimen offers tangible benefits for dermal health. Clinical studies suggest that consistent application leads to improved post-cleansing epidermal barrier resilience, characterized by a reduction in TEWL and enhanced skin comfort. Users can anticipate a more stable dermal microbiome, minimizing the likelihood of dysbiosis-related inflammatory responses. The maintenance of physiological pH levels post-cleansing contributes to an environment less conducive to opportunistic pathogen growth and supports the acid mantle's protective functions. Over several weeks of use, improvements in overall dermal vitality, textural smoothness, and a diminished susceptibility to environmental stressors are observed. This is not merely about superficial cleanliness, but about fostering a deeper, more profound state of dermal harmony and functional integrity.

Sincerely,

The Senior Dermatological Research Team
CureNex (SalmonDNA Australia)